Plague was the first; a creation of the Lord of Hell himself, Malebolgia. Plague, however, could not be controlled. He was an unprecedented force of nature that could cast off the yoke of the most powerful creature in Hell. Realizing his mistake, Malebolgia imprisoned Plague in the darkest pit in Hell for all of eternity. Unfortunately, the machinations of Cogliostro freed Plague and released his evil into the world.